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Related post: roots, which are slightly bitter, are also mildly laxative and are used in various parts of tropical Africa for gastro-intestinal troubles, especially dysentery (Irvine, 1961), and a poultice of the green leaves has been put on sores in Tanzania (Altschul & Lipp, 1982). M. thompsonii (Merrill) Fosberg has been employed medicinally in the Mariana Islands TAltschul & Lipp, 1982). In Brazil leaves of M. ilicifolia Reiss. have been used as a wash for cutaneous cancers (Hartwell, 1968) and in Paraguay extracts of the plant have been used for birth control purposes (Gonzalez Gonzalez t al., 1982). The bark of unidentified Maytenus species has been used against syphilis in Brazil (Altschul & Lipp, 1982). Leaves of M. pseudocasearia Reiss. are used for dysentery in Brazil (Altschul, 1973). Various bark extracts of M. laevis Reiss. have been used in Colombia as an anti-arthritic (Gonzalez Gonzalez e_t al . , 1982). Aqueous extracts of the stems, leaves, and seeds of M. boaria find use in Central Chile for treating internal pain (San Martin., 1983). - 133 - 6. MAJOR CHEMICAL CONSTITUENTS AND MEDICINAL PRODUCTS In addition to maytansine, M. buchananii contains the Where Can I Buy Amoxicillin related compounds maytanprine and may tanbu tine (Kupchan elt al. , I972b), and normaytansine (Sneden & Beemsterboer, 1980). 500mg Amoxicillin Maytansine, maytanprine, and may tanbu tine have also been Amoxicillin Cheap isolated from M. graciliramula S.J.Pei Amoxicillin 500 and Y.H.Li collected in Yunnan (Li Amoxicillin Order source of the compound (Trease & Amoxicillin 500mg Evans, 1978). Other substances isolated include various anti-tumour phenoldienone Amoxicillin 500 Mg triterpenes from several species (via Gonzalez Gonzalez e_t al. , 1982). M. laevis has yielded, in addition to the phenoldicnones, a catechin and some pro-anthocyanidins (Gonzalez Gonzalez et al. , 1982). 7. HARVESTING, CONSERVING AND PREPARATION Maytansine is obtained from the woody stems of Maytenus buchananii. The method used by the United States Department of Agriculture Medical Plant Resources Laboratory for their initial screening of material collected in the Shimba Hills, near Mombasa, Kenya, was to mechanically chip the stems and then transport the material to a semi-desert region for Where To Buy Amoxicillin sun drying before shipment to the United States for processing. There was approximately 40-43% loss of moisture on drying (Perdue, no date). 8. ECONOMICS AND MARKETING Maytansine was first isolated from the seeds of a Maytenus species from Ethiopia. The species has been variously reported as M. serrata (Hochst. ex A. Rich.) Wilczek, M. arbutifolia (Hochst. ex A. Rich.) Wilczek and M. ovata (Wall ex Wight & Arn.) Loes., an Indian species (Spjut. & Perdue, 1976, Perdue, 1976). This uncertainty well illustrates the necessity of providing an identifiable voucher specimen when undertaking a scientific study. The location of the voucher must Amoxicillin Order Online be officially recorded. The yield of maytansine was only 0.2mg/kg and it was considered doubtful if sufficient fruit would be available to meet the demand. - 134 - An improved source was found in the stems of M. buchananii from Kenya with a yield of 1.5mg/kg (Perdue, 1976a). More recent findings suggest that the same source from Tanzania is superior in yield. However, even higher yields of maytansine can be obtained from another member of the Celastraceae , Putterlickia verrucosa (E.Mey, ex Sond.) Szyszyl. from South Africa (Perdue, I976b,). Although stems contain 12.3mg/kg of maytansine, the species was reported to be too widely scattered for Amoxicillin To Buy economic harvesting unless grown under cultivation (Perdue, 1976a, Kupchan t aj.. , 1977c). It is apparently easily cultivated in the USA and may prove to be a be better commercial source of the compound. (Trease & Amoxicillin Amoxil Evans, Amoxil Amoxicillin 1978). The long term future of the Celastraceae, particularly Maytenus buchananii as a source of maytansine must be carelly assessed following the discovery by a research group in Japan that the microsporum Nocardia sp. is a more efficient producer of maytansinoids (Komoda & Kishi, 1980). 9. SILVICS The Amoxicillin Purchase major Buy Cheap Amoxicillin source of supply of maytansine has been M. buchananii in the Shimba Hills of Kenya. There has been no evidence of regeneration from Buy Amoxicillin coppicing following the initial harvesting in Amoxicillin Mg 1972, presumably because the plants are easily broken off at ground level and relatively few stems were left. Cutting stems well above ground level to encourage coppicing was attempted in 1976, no reports to date on the results. Natural regeneration from seed seems probable (Perdue, I976a). Vegetative reproduction by cuttings is practicable. The young plants produced viable seed within a Amoxicillin Buy year under greenhouse conditions near Washington, DC. (Perdue, I976a). Field trials in Kenva suggested that plants propagated from seeds did better than plants from cuttings. Interplanting with shade trees such as Prosopis spp. or Leucaena leucocephala are beneficial, resulting in better growth and earlier maturity (Haller, 1978). 10. MAJOR DISEASES No problems evident as yet. Some insect damage reported, but can be controlled (Perdue, 1976a). 11. OTHER USES The fruits of M. senegalensis are eaten in Botswana and the yellow-white wood, being hard and durable and with a fine grain, is used for walking sticks (Irvine, 1961). In Lesotho, the wood of M. acuminata (L.f.)Loes., M. heterophylla (Ecklon & Zeyher) N. Robson, M. undata (Thunb. ) Blake lock (and other species is used for building and as firewood and fighting sticks (Jacot Guillarmod, 1971) and that of M. senegalensis (Lam.) Exell is an important boxwood Get Amoxicillin in Malawi (Williamson, 1975). In dry areas of Sudan, M. senegalensis is browsed by goats and camels, and in Tanzania stock eat the leaves
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